Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, A new synthetic method of this compound is introduced below., Recommanded Product: 122-05-4
General procedure: 3.1.1.12; 2,5-Bis[6-(4,5-dihydro-1H-imidazol-2-yl)1,3-benzothiazol-2-yl]pyrazine dihydrochloride (3l) To a solution of the free base prepared by method A in acetic acid (40 mL) concd HCl (2.0 mL) was added and stirred for 2 h. The resulting precipitate was filtered off, washed with acetone and dried. Crystallization from water/1 M HCl/acetone mixture gave pure compound 3l 136 mg (46.0%) as yellow solid: mp > 300 C. 1H NMR (300 MHz, DMSO-d6) (delta ppm): 10.65 (br s, 4H, H-Amd), 9.70 (s, 2H, H-Pyr), 8.86 (d, 2H, J = 1.4 Hz, H-Bt), 8.48 (d, 2H, J = 8.7 Hz, H-Bt), 8.10 (dd, 2H, J = 1.5 Hz, J = 8.6 Hz, H-Bt), 4.06 (s, 8H, H-CH2). LC-MS (ESI) m/z: 483.3 [(M + H+) calcd for free base C24H18N8S2, 482.11]. Analysis calcd for C24H20Cl2N8S2 * 2H2O (591.54): C, 48.73; H, 4.09; N, 18.94, Cl, 11.99. Found C, 48.91; H, 4.05; N, 18.94; Cl, 11.72%.
The synthetic route of 122-05-4 has been constantly updated, and we look forward to future research findings.