Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16298-03-6, name is Methyl 2-aminopyrazine-3-carboxylate, A new synthetic method of this compound is introduced below., Product Details of 16298-03-6
Example 1 [0069] Examples 1-4 illustrates Reaction Scheme 1 where the SUBSTITUENTS are as listed in the Table below. The compounds in bold are found in the Reaction Schemes. Compound R Substitution R2 Substitution Ib, If, Ij, 17 para F H Ic, Ig, Ik, 12 meta CF3 H Id, Ih, Il, 11 ortho Cl H Ie, Ii, Im, 13 meta F H Synthesis of Compound 17 [0070] Pyridine (2. 1 ML, 0. 025 mol) was added to methyl 3-AMINO-2-PYRAZINE carboxylate IA (3G, 0. 020 mol) in dry CHC13 (50 ML) and stirred for 5 minutes under nitrogen at room temperature. 4-fluorobenzoyl chloride (3. 5MOL, 0. 029 mol) was added slowly to the reaction mixture. The mixture was stirred for 18 hours under nitrogen. The reaction mixture was washed with 5percent Na2CO3 solution (2 X 200 ML), water (2 X 200 ML), brine (2 X 200 ML), dried (MGS04) and the solvent was removed IN VACUO. The desired product Ib was obtained by RE- CRYSTALLIZATION from ethyl acetate (1. 6G, 30percent yield). EIMS : M+ 275
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.