Electric Literature of 939412-86-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 939412-86-9, name is (3-Chloropyrazin-2-yl)methanamine hydrochloride belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
Intermediate 17&18. Step 3: (6R.8aS)-N-((3-chloropyrazin-2-yl)methyl)-l-methyl-3-oxohexahydro-lH-oxazolor3.4- alpyridine-6-carboxamide To a solution of (6R,8aS)-l-methyl-3-oxohexahydro-lH-oxazolo[3,4-a]pyridine-6-carboxylic acid (600 mg, 3.02 mmol) in dry DCM (12 mL) at 5 C, Oxalyl dichloride (1.15 g, 9.04 mmol) was added drop wise and DMF (3 drops) was added. The reaction mixture was stirred at 30 C for 2 h. The reaction mixture was concentrated in vacuo to give crude acyl chloride. The solution of crude acyl chloride in DCM (3 ml) was added to a solution of (3-chloropyrazin-2- yl)methanamine hydrochloride (594 mg, 3.32 mmol), TEA (640 mg, 6.04 mmol) in DCM (10 ml), and then the reaction mixture was stirred at 30 C for 12h. The reaction was dulited with DCM (20 mL) and H20 (20 mL), the organic layer was washed with brine (20 mL), dried over Na2SC>4, The crude product was purified by column chromatography on silica gel eluted with PE/THF (100 %-40 %) to give (6R,8aS)-N-((3-chloropyrazin-2-yl)methyl)-l-methyl-3- oxohexahydro-lH-oxazolo[3,4-a]pyridine-6-carboxamide. l NMR (400MHz, CD3OD) delta = 8.55 (d, J=2.5 Hz, 1H), 8.36 (d, J=2.5 Hz, 1H), 4.77 (quin, J=6.8 Hz, 1H), 4.65 (s, 2H), 4.30 (quin, J=6.2 Hz, 1H), 3.98 – 3.90 (m, 1H), 3.78 – 3.70 (m, 1H), 3.12 – 3.00 (m, 1H), 2.51 (ttd, J=4.1, 12.1, 16.0 Hz, 1H), 2.19 – 2.07 (m, 1H), 2.00 (dd, J=3.5, 13.1 Hz, 1H), 1.81 – 1.66 (m, 2H), 1.55 – 1.39 (m, 3H), 1.35 (d, J=6.5 Hz, 2H) ppm.
The synthetic route of (3-Chloropyrazin-2-yl)methanamine hydrochloride has been constantly updated, and we look forward to future research findings.