Related Products of 19745-07-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19745-07-4 name is 2,5-Dichloropyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of A-63 (1 g, 6.71mmol), [4-(trifluoromethoxy)phenyl]- boronic acid (1.52 g, 7.38 mmol), Pd(dppf)Cl2.CH2Cl2 (822.23 mg, 1.01 mmol) and Cs2C03 (4373.74 mg, 13.42 mmol) in 1,4-dioxane (20 mL) and water (4 mL) under N2 was stirred at 90 C for 16 hours. After cooling, the reaction mixture was diluted with EtOAc (20 mL), and filtered through a Celite pad, eluted with EtOAc (20 mL), and concentrated. The residue was purified by flash chromatography on silica gel (EtOAc in PE = 0percent to 3percent to 8percent) to afford A-108 (250 mg, 0.91 mmol) as a solid. 1H NMR (400MHz, CDC13) _ = 8.79 (d, 1H), 8.65 (d, 1H), 8.05 (d, 2H), 7.37 (d, 2H)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,5-Dichloropyrazine, and friends who are interested can also refer to it.