Electric Literature of 19847-12-2, A common heterocyclic compound, 19847-12-2, name is Pyrazinecarbonitrile, molecular formula is C5H3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: TFA (0.75mmol) was added to a DCM/distilled H2O solution(2.5 mL, v/v = 1:1) of 1a (0.5mmol), and then stirred for 15 min. 2a (0.75mmol), K2S2O8 (1.5mmol) were added under air, sequentially an aqueous solution of FeSO4*7H2O in distilled H2O (1.25 mL) was slowly added by syringe pump(10 muL min-1). After complete addition, the reaction mixture was stirred for 5 h at ambient temperature. The mixture was neutralized by NaOH solution (1.0 M), the obtained aqueous phase was extracted with ether. The combined ethereal solution was dried over Na2SO4 and filtered. After evaporating the solvent, the arylated products 2-3aa and 3-3aa were isolated by flash chromatography (hexane:EtOAc = 5:1) in 67% and 27%yields, respectively.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.