Application of 912773-21-8, A common heterocyclic compound, 912773-21-8, name is 2-Bromo-5-chloropyrazine, molecular formula is C4H2BrClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a suspension of 2-bromo-5-chloropyrazine (2.02 g, 10.44 mmol) in diethylether (30 mL)at -78 oC was added n-butyllithium (4.26 mL, 10.65 mmol) over 10 mm.The resulting mixture was stirred at -78 oC for 15 mm before propan-2-one (1.9 17 mL, 26.1 mmol) was indroduced over 2 mm. The mixture was stirred at -78 oC for 15 mm and then at rt for 30 mm. The reaction was quenched with saturated NH4C1 solution (30 mL), and the solution was extracted with ethyl acetate (4 x 40 mL). The combined extract wasdried over anhydrous Na2SO4. The desired product, 2-(5-chloropyrazin-2-yl)propan-2-ol (0.507 g, 2.94 mmol, 28.1 % yield), was isolated by ISCO (120 g silica gel, solid loading, 10-40% ethyl acetate/hexane).
The synthetic route of 912773-21-8 has been constantly updated, and we look forward to future research findings.