Adding a certain compound to certain chemical reactions, such as: 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1379338-74-5, Quality Control of 5,7-Dichloropyrido[3,4-b]pyrazine
1,1-dimethylethyl (3R)-3-(aminomethyl)-4-methyl-1-piperazinecarboxylate (143 mg, 0.624 mmol) and diisopropylethylamine (0.131 ml, 0.750 mmol) were added to a solution of 5,7-dichloropyrido[3,4-b]pyrazine (100 mg, 0.500 mmol) in dry N-methyl-2-pyrrolidone (NMP) (2 ml). The reaction was heated at 130 C. in the microwave for 30 min. After cooling, the reaction was partitioned between ethyl acetate and water. The aqueous layer was extracted with ethyl acetate (*2). The combined organics were washed with brine, dried using a hydrophobic frit and evaporated to give an orange oil. The residue was loaded in dichloromethane and purified on silica (25 g) using a 0-100% ethyl acetate/cyclohexane gradient. Appropriate fractions were combined and evaporated to give the title compound as yellow oil (162 mg). LCMS (Method A): Rt=1.2 min, MH+=393/395
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5,7-Dichloropyrido[3,4-b]pyrazine, other downstream synthetic routes, hurry up and to see.