Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 74290-67-8, name is 2-Amino-5-bromo-3-methylpyrazine, A new synthetic method of this compound is introduced below., SDS of cas: 74290-67-8
Example 31 N-(3-((5-amino-6-methylpyrazin-2-yl)ethynyl)-2,4-difluorophenyl)-5-chloro-2-methylbenzenesulfonamide A mixture of 5-chloro-N-(3-ethynyl-2,4-difluorophenyl)-2-methylbenzenesulfonamide (100 mg), 5-bromo-3-methylpyrazin-2-amine (55 mg), dichlorobis(tricyclohexylphosphine)palladium(II) (14 mg), cesium carbonate (381 mg) and DMSO (2 mL) was stirred under microwave irradiation at 120 C. for 2 hr. After cooling to room temperature, the reaction mixture was filtered through celite, and the filtrate was diluted with water and extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, dried over magnesium sulfate and concentrated to give a residue. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) and further purified by HPLC (C18, mobile phase: water/acetonitrile (0.1% TFA-containing system)). Fractions containing the object product were collected, neutralized with a saturated aqueous sodium hydrogen carbonate solution, and extracted with ethyl acetate. The obtained organic layer was dried over magnesium sulfate and concentrated to give a residue. The residue was washed with ethyl acetate/IPE/hexane to give the title compound (32 mg). 1H NMR (300 MHz, DMSO-d6) delta 2.29 (3H, s), 2.57 (3H, s), 6.87 (2H, s), 7.13-7.33 (2H, m), 7.47 (1H, d, J=8.1 Hz), 7.58-7.68 (2H, m), 8.04 (1H, s), 10.56 (1H, s).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.