Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4744-50-7, name is 2,3-Pyrazinecarboxylic anhydride, A new synthetic method of this compound is introduced below., name: 2,3-Pyrazinecarboxylic anhydride
12H-pyrazino[2′,3′:3,4]pyrrolo[1,2-a]perimidin-12-one (1): Naphthalene-1,8-diamine (40 mg, 0.057 mmol), furo[3,4-b]pyrazine-5,7-dione (40 mg, 34 mmol), and 10ml pyridine were added into a round bottom flask and heated to reflux. After 4h, the reaction mixture cooled down and the solvent was removed under reduced pressure. The crude residue was dispersed in 50 mL methanol with strong agitation. After 1h, the solid was collected by vacuum filtration and purified using silica-gel column chromatography with methylene chloride:methanol (50:1) to afford 1 (28 mg, 39%) as a red powder. 1H NMR (CDCl3, 400 MHz) delta 9.06 (d, 2H), 8.67 (d, 1H), 7.65-7.71 m (m, 3H), 7.54-7.57 (m, 2H); FT-IR 1732, 1654, 1402, 1375, 1131, 831, 760, 423 cm-1; Mp > 250oC; MALDI-TOF MS exact mass (M + H): 272.28; calcd. Mass: 271.27.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Zhao, Jian-Feng; Liu, Yi; Soh, Jiayun Bethia; Li, Yong-Xin; Ganguly, Rakesh; Ye, Kai-Qi; Huo, Fengwei; Huang, Ling; Tok, Alfred Iing Yoong; Loo, Joachim Say Chye; Zhang, Qichun; Tetrahedron Letters; vol. 53; 45; (2012); p. 6044 – 6047;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem