Application of 1458-16-8, The chemical industry reduces the impact on the environment during synthesis 1458-16-8, name is Methyl 3-amino-6-iodopyrazine-2-carboxylate, I believe this compound will play a more active role in future production and life.
To a methanol (10 ml) and tetrahydrofuran (10 ml) solution of 3-amino-6-iodopyrazine-2-carboxylic acid methyl ester (see Patent Document:)(2.0 g, 7.16 mmol), a 1 M aqueous sodium hydroxide solution (14.3 ml) was added under ice cooling and the mixture was stirred for 2 hours under ice cooling. The reaction solution was charged with a 1 M aqueous hydrochloric acid solution to render the reaction system acidic and concentrated to obtain crude 3-amino-6-iodopyrazine-2-carboxylic acid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-amino-6-iodopyrazine-2-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Taisho Pharmaceutical Co. Ltd.; Nissan Chemical Industries, Ltd.; EP2157090; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem