Related Products of 221136-66-9, These common heterocyclic compound, 221136-66-9, name is Ethyl 2-(3-bromo-6-methyl-2-oxopyrazin-1(2H)-yl)acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
{6-Methyl-2-oxo-3-[2-(pyridin-2-yloxy)-ethylamino]-2H-pyrazin-1yl}-acetic acid ethyl ester. A solution of 70.0 mg (0.254 mmol) of (3-bromo-6-methyl-2-oxo-2H-pyrazin-1-yl)-acetic acid ethyl ester (for preparation see Synth. Comm.; 30; 2000; 3171-3180) and 85.2 mg (0.560 mmol) of 2-(pyridin-2-yloxy)-ethylamine in 5 mL of ethanol is heated over night at 130 C in a sealed tube. After allowing to cool down, the solution is diluted with 10 mL of water and then extracted three times with ethyl acetate. The organic phase is separated, dried with sodium sulfate and the solvent is removed under reduced pressure. The crude mixture is purified using flash chromatography (silica gel, eluent: 50% ethyl acetate in cyclohexane) to afford 22.0 mg (26%) of the title compound. LC/MS (I) rt 2.40, m/z 333 (M+H).
The synthetic route of 221136-66-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Graffinity Pharmaceuticals Aktiengesellschaft; EP1526131; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem