Related Products of 767340-03-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 767340-03-4, name is (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
Step C: Preparation of r2RV4-oxo-4-f3-(‘trifluoromethyl)-5.6-dihvdrori,2,41triazolor4.3- a1pyrazin-7(8H)-yl]-l -(2 A5-trifluorophenv0butan-2-amine (2-5) Into a 250 ml flask were charged chloro(l,5-cyclooctadiene)rhodium(I) dimer{[Rh(cod)Cl]2}(46 mg, 0.093 mmol) and (R,S) t-butyl Josiphos (106 mg, 0.196 mmol), ammonium chloride (12.5 mg, 0.234 mmol), and enamine amide (25 g, 61.8 mmol) under a nitrogen atmosphere. Degassed MeOH was then added (225 mL) and the mixture was stirred at room temperature for 1 h. The slurry was transferred into a hydrogenator under nitrogen. After degassing three times, the enamine amide was hydrogenated under 100 psi hydrogen gas at 50 0C for 18 h. Assay yield was determined by EtaPLC to be 97% and optical purity to be 94% ee.The optical purity was further enhanced in the following manner. The methanol solution from the hydrogenation reaction (18 g in 180 mL MeOH) was concentrated and switched to methyl t- butyl ether (MTBE) (45 mL). Into this solution was added aqueous Eta3PO4 solution (0.5 M, 95 mL). After separation of the layers, 3NNaOH (35 mL) was added to the water layer, which was then extracted EPO
The synthetic route of (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK & CO., INC.; WO2006/81151; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem