In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 19745-07-4 as follows. Recommanded Product: 19745-07-4
2.3 g of benzyl alcohol was added under ice-cooling to a mixture of 3.0 g of 2,5-dichloropyrazine, 880 mg of sodium hydride (60percent, oil) and 50 mL of NMP.The reaction mixture was warmed to room temperature and stirred at room temperature for 5 hours.Water was added to the obtained reaction mixture, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure.The obtained residue was subjected to silica gel chromatography to obtain 3.1 g of Intermediate 1 represented by the following formula.
According to the analysis of related databases, 19745-07-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; NAKAJIMA, YUJI; (211 pag.)JP2017/114883; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem