Some common heterocyclic compound, 41270-66-0, name is 5-Chloro-2,3-diphenylpyrazine, molecular formula is C16H11ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 5-Chloro-2,3-diphenylpyrazine
116] Step 1. 2-(1.1.2.2.3.3.4.4-dR-4-((5.6-Diphenylpyrazin-2-viyperdeutero-propan-2- yl)amino)butan-l-ol (12a). To a solution of commercially available 5-chloro-2,3- diphenylpyrazine (10) (0.56 g, 2.10 mmol) in NMP (2.1 mL) was added dis-aminoalcohol 11a (0.46 g, 3.15 mmol, 1.5 equiv, prepared as described in Example 8). The reaction vessel was sealed and heated to 190 0C for 15 hours, then cooled to ambient temperature. The mixture was diluted with ice water and extracted with Et2O (3 x 20 mL). The combined organic layers were washed successively with water and brine. The resulting organic layer was dried (MgSO4), filtered and concentrated in vacuo. The resulting residue was purified by column chromatography (SiO2, 30-50% EtO Ac/heptane) to afford 12a (0.13 g, 16%). MS (M+H): 377.0.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 41270-66-0, its application will become more common.
Reference:
Patent; CONCERT PHARMACEUTICALS, INC.; HARBESON, Scott L.; MASSE, Craig E.; LIU, Julie F.; WO2011/17612; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem