Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 136927-64-5, name is 1-Chloropyrrolo[1,2-a]pyrazine, This compound has unique chemical properties. The synthetic route is as follows., Formula: C7H5ClN2
Compound C21 (500 mg, 2.22 mmol), 1-chloropyrrolo[1,2-a]pyrazine (339 mg, 2.22 mmol), cesium carbonate (796 mg, 2.44 mmol), and palladium(ll) acetate (53 mg,0.22 mmol) were combined in 1,4-dioxane (15 mL), and the solution was degassed with nitrogen for 15 minutes. Di-tert-butyl[3,4, 5,6-tetramethyl-2?, 4?,6?-tri(propan-2-yl) bi phenyl2-yl]phosphane (214 mg, 0.444 mmol) was added to the reaction mixture, which wasthen degassed for an additional 2 minutes. The reaction mixture was heated to 100 00 in a microwave reactor for 6 hours, whereupon it was cooled to room temperature andfiltered through diatomaceous earth. The filter cake was washed with ethyl acetate, andthe combined filtrates were concentrated in vacuo. Silica gel chromatography (Gradient:20% to 80% ethyl acetate in heptane) was followed by three triturations with heptane;the resulting material was purified again using silica gel chromatography (Gradient:50% to 70% ethyl acetate in heptane) to provide the product as a pale yellow solid.Yield: 361 mg, 1.06 mmol, 48%; 13. In this case, 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene was used in lieu ofdi-teit-butyl[3,4, 5, 6-tetramethyl-2?, 4? ,6?-tri(propan-2-yl)biphenyl-2-yl]phosphane.14. 4-Bromo-3-fluorophenol was protected as its tri(propan-2-yl)]silyl ether, which was converted to [3-fluoro-4-(4,4, 5,5-tetramethyl- 1, 3,2-dioxaborolan-2- yl)phenoxy][tri(propan-2-yl)]silane using the chemistry described for synthesis of C2 from Cl. Suzuki reaction with 5-bromo-6-methylpyrim idine-4-carbonitrile, followed bydesilylation using tetraethylammonium fluoride, afforded the requisite 5-(2-fluoro-4- hydroxyphenyl)-6-methylpyrimidine-4-carbonitrile.
According to the analysis of related databases, 136927-64-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PFIZER INC.; GRAY, David Lawrence Firman; DAVOREN, Jennifer Elizabeth; DOUNAY, Amy Beth; EFREMOV, Ivan Viktorovich; MENTE, Scot Richard; SUBRAMANYAM, Chakrapani; WO2015/166370; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem