Brief introduction of Pyrazin-2-ylmethanol

The synthetic route of 6705-33-5 has been constantly updated, and we look forward to future research findings.

Electric Literature of 6705-33-5,Some common heterocyclic compound, 6705-33-5, name is Pyrazin-2-ylmethanol, molecular formula is C5H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5-Fluoro-2-(pyrazin-2-ylmethoxy)nicotinic acid (211)To a solution of 2-chloro-5-fluoronicotinic acid (1.15g, 6.6mmol) in THF (20ml) under a N2 atmosphere was added 2-pyrazinylmethanol (l .Og, 9.2mmol) followed by a portion-wise addition of NaH (60% dispersion in mineral oil, 0.79g, 20mmol). The resulting suspension was stirred at room temperature for 2 d and then quenched with 1 M NaOH (10ml). After washing with DCM (x2), the aqueous layer was acidified with concentrated HC1 until the product precipitated out of solution (~ pH 5). The solids were filtered, washed with ?() and then dried under high vacuum to afford the title compound (0.5 lg, 32%) as a cream solid.NMR delta 8.78 (IH, d, J 1.5), 8.58 (IH, dd, J 1.5, 2.5), 8.54 (IH, d, J2.5), 8.30 (IH, d, J 3.0), 8.03 (IH, dd, J3.0, 8.2), 5.49 (2H, s);MS (m/e) 250 [M+H]+, Rt 0.62 (QC Method 1)

The synthetic route of 6705-33-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ARROW THERAPEUTICS LIMITED; ASTRAZENECA UK LIMITED; BARNES, Michael, Christopher, Stratton; FLACK, Stephen, Sean; FRASER, Ian; LUMLEY, James, Andrew; PANG, Pui Shan; SPENCER, Keith, Charles; TIBERGHIEN, Nathalie, Anne, Laure; TOMKINSON, Gary, Peter; WO2011/151651; (2011); A1;,
Pyrazine – Wikipedia,
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