Electric Literature of 36070-80-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of lenalidomide (0.2g, 0.77 mmol) in DMF (4 mL) was added 5-chloropyrazine-2-carboxylic acid (0.15g, 0.95 mmol), HATU, (0.29g, 0.77 mmol), and DIPEA (0.27mL, 1.54 mmol). The reaction was stirred at room temperature for 1 hr before it was quenched with saturated NH4C1 (5 mL). The mixture was extracted with EtOAc (10 mLx3), and the combined organic phase was dried over Na2S04 and concentrated. Column chromatography gave 5-chloro-N- (2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-4-yl)pyrazine-2-carboxamide (0.1 g, 33%).
The chemical industry reduces the impact on the environment during synthesis 5-Chloropyrazine-2-carboxylic acid. I believe this compound will play a more active role in future production and life.
Reference:
Patent; SYNTA PHARMACEUTICALS CORP.; CHIMMANAMADA, Dinesh, U.; YING, Weiwen; ZHANG, Junyi; KOWALCZYK-PRZEWLOKA, Teresa; JIANG, Jun; OSMAN, Sami; LU, Genliang; VUTUKURI, Dharma; LOCH, James; CHEN, Shoujun; WO2015/38649; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem