Application of 344940-70-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 344940-70-1 name is 5-Bromo-3-phenylpyrazin-2-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Into a flask, purged with an inert atmosphere of nitrogen, was placed 5-bromo-3-phenylpyrazin-2-amine (300 mg, 1.20 mmol) in EtOH (5.22 mL). 2-Bromo-l,l-diethoxyethane (372 mu, 2.40 mmol) and HBr in water (950 mu, 8.40 mmol) were added. The mixture was warmed at 85C. After 2.5 h, the reaction was cooled to ambient temperature and diluted with EtOAc. The mixture was further cooled to 0C and slowly quenched with saturated aqueous NaHC03 until the pH was adjusted to 9. The resulting solution was extracted with EtOAc (3X). The organic layers were combined and dried over anhydrous sodium sulfate. The solid was filtered and the filtrate was concentrated in vacuo to dryness. The residue was purified by silica gel chromatography with EtOAc:hexanes (0-70%) to afford the title compound.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromo-3-phenylpyrazin-2-amine, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; CAMPBELL, Brian, T.; DONG, Guizhen; GARFUNKLE, Joie; KIM, Alexander; ORNOSKI, Olga; PARKER, Dann, L., Jr.; RAGHAVAN, Subharekha; XU, Libo; YANG, Zhiqiang; (191 pag.)WO2015/187470; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem