Synthetic Route of 957344-74-0, These common heterocyclic compound, 957344-74-0, name is 5,8-Dibromoimidazo[1,2-a]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 3 (5-Bromo-imidazo[l,2-a]pyrazin-8-yl)-[4-(4-isopropyl-piperazin-l-yl)-phenyl] -amine[00395] A solution of 5,8-dibromo-imidazo[l,2-a]pyrazme (0 134g, 0 48mmol), 4-(4-isopropyl- piperazm-l-yl)-phenylamine (0 118g, 0 54mmol) and dnsopropylethylamme (0 093mL, 0 54mmol) is stirred at 9O0C for 18 hours The reaction mixture is concentrated in vacuo and partitioned between DCM and sat NaHCO3 The organic layer is washed with brine, d?ed over MgSO4, filtered and concentrated The residue is pu?fied by silica gel column chromatography eluting with 98 2 DCM MeOH to afford the title compound (0 086 g, 43%)
The synthetic route of 957344-74-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GALAPAGOS N.V.; WO2007/131991; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem