Electric Literature of 33332-25-1, A common heterocyclic compound, 33332-25-1, name is Methyl 5-chloropyrazine-2-carboxylate, molecular formula is C6H5ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
This compound was prepared by following Suzuki coupling mechanism where methyl 5-(chloropyrazine)-2-carboxylate, a commercially available starting material 36 7 (2g, 0.0115mmol) was reacted with 44 phenyl boronic acid (1.4g, 0.0115mmol) using 45 bis(triphenylphosphine) palladium(II)dichloride (0.163g, 0.0002mmol) as catalyst, 146 potassium carbonate (2.4g, 0.01737mmol) as base and 1,4-dioxane as solvent for 12h at 100C. After completion of the reaction, the solvent was evaporated and crude was extracted in 106 ethyl acetate and washed with water. The organic layer was dried over sodium sulfate and crude was purified by column chromatography (hexane: EtOAc; 9:1) to get 1g of pure white crystalline solid intermediate 47 19 (yield 40.16%). 1H NMR (400MHz, DMSO-d6) delta 9.42 (d, J=1.4Hz, 1H), 9.25 (d, J=1.4Hz, 1H), 8.27-8.23 (m, 2H), 7.62-7.57 (m, 3H), 3.95 (s, 3H). C12H12N2O2 [M]: 214.22; MS (ESI) m/z: [M+H]+: 215.10.
The synthetic route of 33332-25-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Trivedi, Prakruti; Adhikari, Nilanjan; Amin, Sk. Abdul; Jha, Tarun; Ghosh, Balaram; European Journal of Pharmaceutical Sciences; vol. 124; (2018); p. 165 – 181;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem