Adding a certain compound to certain chemical reactions, such as: 6863-73-6, name is 3-Chloropyrazin-2-amine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6863-73-6, Recommanded Product: 3-Chloropyrazin-2-amine
Step B: Preparation of 8-chloro-imidazo[ 1 ,2-a]pyrazine To a stirred suspension of 3-chloropyrazin-2-amine (107.5 g, 129.6mmol) in water (2500 mL) and THF (236 mL) at rt was added ethyl 2-bromo-1 ,1 -diethoxyethane (375 mL, 197 mmol) in one portion. After stirring at reflux for 4 h and 5 h at rt, the solution was adjusted to pH 8 by potassium carbonate, extracted with DCM (4 x 1000 mL9, dried over sodium sulphate, filtered and evaporated. Yield 132.9 g (104 %) 8-chloro-imidazo[1 ,2-a]pyrazine: 1H-NMR (300 MHz, d6-DMSO): delta =8.62 (d, 1 H), 8.24 (d, 1 H), 7.82 (d, 1 H), 7.69 (d, 1 H) ppm.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloropyrazin-2-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; KOPPITZ, Marcus; KLAR, Ulrich; JAUTELAT, Rolf; KOSEMUND, Dirk; BOHLMANN, Rolf; BADER, Benjamin; LIENAU, Philip; SIEMEISTER, Gerhard; WO2012/80229; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem