These common heterocyclic compound, 14508-49-7, name is 2-Chloropyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C4H3ClN2
In a sealed tube, 2-chloropyrazine (1.0 g, 8.7 mmol, 1 equiv) was heated withethanolic methylamine (33% w/w; 4.0 g, 43.6 mmol, 5 equiv) at 95 C for 1 h.Solvent and excess of methylamine were then removed under reduced pressure. Theresidue was then dissolved in dichloromethane and washed three times with water.The organic phase was then evaporated under reduced pressure and the crude productwas further purified by flash chromatography on silica gel (EtOAc/Et2O= 1:6 to 1:4).The product S2 was obtained as a colorless oil (0.73 g, 6.7 mmol, 77% yield), whichsolidified as a light brown solid. The spectra are in agreement with the literaturereport.1
The synthetic route of 2-Chloropyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Article; Huang, Qi; Qin, Ling; Zard, Samir Z.; Tetrahedron; vol. 74; 40; (2018); p. 5804 – 5817;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem