Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 153800-11-4, name is 2-Ethynylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 2-Ethynylpyrazine
To a solution of 223(100mg, 0347mmo1), 10(361mg, 0.347mmo1) in 20 mL of Et3N was added Pd(PPh3)2C12 (244mg, 0.347mmo1) and CuT (66.1mg. 0347mmo1). The mixture was protected under N2 atmosphere, then was heated at 70C for 4 hours. TLC analysis showed complete conversion of starting material to a major product. The reaction mixture was then concentrated in vacuo. The crude product was purified by PrepHPLC to give the target product Compound88(0mg, yield: 2180%),LCMS: m/z 265 (M+HY;1H NMR (400 MHz, CDCI3): oe 8.74 (d, J= 1.2 Hz, 1H), 8.588.57 (m, IH), 8.49 (d, J= 2.4Hz, 11:1), 813 (s, 1H), 793 (s, 1H), 768.-764 (in, 2H), 7.18 (t,J: 8.6Hz, 2H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 153800-11-4.
Reference:
Patent; HUA MEDICINE (SHANGHAI) LTD.; CHEN, Li; JIN, Xiaowei; (176 pag.)WO2017/117708; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem