Related Products of 61655-72-9,Some common heterocyclic compound, 61655-72-9, name is 6-Chloro-N,N-dimethylpyrazin-2-amine, molecular formula is C6H8ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 6- cMoro-N,N-dimethylpyrazin-2-amine (11-2) ( 1 g, 6.3 mmol) and pyridin-4-yl boronic acid (1.06 g, 8.6 mmol, 1.35 eq) were suspended in dimethoxyethane and water (10:1 ) in a heavy wall pressure vessel. The reaction mixture was purged with argon for 10 min. Sodium carbonate (2.0 g, 1 ,6 mmol, 3 eq) and tetrakis(triphenylphosphine) palladium (0.650 g, 0.57 mmol) were added and the reaction mixture was heated at 1 10 ¡ãC for 15 hrs. The reaction mixture was cooled to ambient temperature and filtered though a medium frit sintered glass funnel filled with Celite. The filtrate was concentrated under reduced pressure, dissolved in dichloromethane and washed with water (3 x 5 mL). The organic layer was dried with sodium sulfate and concentrated under reduced pressure. The product 11-3 was purified over silica gel column using ethylacetate and hexane (2:3 v/v) eluent. The title compound 11-3 was obtained as yellow solid (1 , 1 g) in 75percent (gravimetric) yield. HPLC (tr/purity): 10.7 min, > 90percent (HPLC method A); ESI m/z (MeOH) : 201.10 (MH ).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6-Chloro-N,N-dimethylpyrazin-2-amine, its application will become more common.
Reference:
Patent; THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; ARANCIO, Ottavio; WATTERSON, Daniel, Martin; PELLETIER, Jeffrey, Claude; ROY, Saktimayee, Mitra; WO2014/145485; (2014); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem