Introduction of a new synthetic route about 3-Chloropyrazine-2-carbaldehyde

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 121246-96-6.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 121246-96-6, name is 3-Chloropyrazine-2-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 3-Chloropyrazine-2-carbaldehyde

PREPARATION 14; EPO 4-Methyl-3,4,5,6-tetrahvdro-2H-?,2’lbipyrazinyl-3′-carbaldehvde;.S-Chloro-pyrazine^-carb-aldehyde (Turck, et al., Synthesis 1988, 881-4) (6.01 g, -40 mmol), N-methylpiperazine (6.6 mL, 59.4 mmol) and K2CO3 (8.3g, 60.0 mmol) were refluxed for 1h in dioxane (250 mL). After cooling, the mixture was filtered and concentrated to an orange oil. This was dissolved in EtOAc (500 mL) and washed with water (4×150 mL) and brine, dried (MgSO4) and concentrated. Chromatography with 5% MeOH/ CH2CI2 gave 3.34 g (40%) of PP14 as a dark red oil : NMR (CDCI3) 9.94 (s, 1 H), 8.18 (d, J= 2.1 Hz, 1 H), 8.08 (d, J = 2.1 Hz, 1 H), 3.59 (t, J= 5.2 Hz, 4H), 2.53 (t, J = 5.0 Hz, 4H), 2.32 (s, 3H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 121246-96-6.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2006/48727; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem