Adding a certain compound to certain chemical reactions, such as: 59303-10-5, name is 2-Chloro-5-methylpyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 59303-10-5, Recommanded Product: 59303-10-5
PREPARATION EXAMPLE 2: N-rri -(5-methoxypyrazin-2-vncvclopropyllmethyll-2- (trifluoromethyl)benzamide (compound A.26)Step 1 : 2-(bromomethyl)-5-chloro-pyrazine5.0 g of 2-chloro-5-methyl-pyrazine, 6.9 g of N-bromosuccinimide and 0.33 g of 2,2′- azobis(2-methylpropionitrile) were suspended in 67 ml of chlorobenzene. The yellow mixture was heated to 130C and stirred for 4 hours. Then the mixture was cooled to ambient temperature, diluted with ethyl acetate and an aqueous solution of sodium thiosulfate was added. After extraction the phases were separated, the organic layer was washed with brine, dried over anhydrous sodium sulphate and evaporated. The residue was purified by flash chromatography on silica gel with cyclohexane/ethyl acetate (2:1 ) as eluent. Thus, 5.52 g of 2-(bromomethyl)-5-chloro-pyrazine was obtained as a brown oil. 1H-NMR (CDCI3): 8.57 ppm (s, 1 H), 8.49 ppm (s, 1 H), 4.54 ppm (s, 2H).
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Reference:
Patent; SYNGENTA PARTICIPATIONS AG; LOISELEUR, Olivier; PITTERNA, Thomas; O’SULLIVAN, Anthony, Cornelius; LUKSCH, Torsten; WO2013/64518; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem