Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 109838-85-9, name is (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C9H16N2O2
General procedure: Butyl lithium (1.6 N solution in hexane, 1.05 equiv) was added to a solution of (2R)-1 (1 equiv) in anhydrous THF (5 mL) cooled to ?78¡ãC, and the mixture was stirred for 45 min. Imine 2a?f (1 equiv) in THF (4 mL) was added, and the mixture was stirred at ?78¡ãC for 8h. The reaction mixture was allowed to warm to ?10 ¡ãC, after which a pH=7 phosphate buffer solution (10 mL) was added, and the mixture was extracted with ethyl acetate (3¡Á10 mL). The organic phase was separated and dried with Na2SO4, and the solvent was evaporated in vacuo. Compounds 3, 4 were purified by means of flash chromatography (SiO2, CH2Cl2/hexane=40/60 for 3a (Rf 0.2) and 4a (Rf 0.4); CH2Cl2/ethyl acetate=95/5 for 3d (Rf 0.4) and 4d (Rf 0.5), 3e (Rf 0.5) and 4e (Rf 0.6); CH2Cl2/ethyl acetate=98/2 for 4f (Rf 0.6)).
According to the analysis of related databases, 109838-85-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; Cremonesi, Giuseppe; Dalla Croce, Piero; Gallanti, Maddalena; La Rosa, Concetta; Tetrahedron; vol. 70; 11; (2014); p. 2054 – 2058;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem