Electric Literature of 22047-25-2, These common heterocyclic compound, 22047-25-2, name is Acetylpyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: 1-(Pyrazin-2-yl)ethan-1-one or 1-(5-alkylpyrazin-2-yl)ethan-1-one (0.01 mol) and thecorresponding halogenated benzaldehyde (0.01 mol) were dissolved in pyridine (4.4 mL).Diethylamine (0.01 mol) was added, and the reaction mixture was stirred at 80-120 C for 1 h. Aftercooling, the mixture was poured into ice water (200 mL), acidified to pH 3 with a few drops of aceticacid, and then refrigerated for 24 h. The separation of crude products from water depended on theircharacter. Solids were filtered off and crystallized from anhydrous ethanol, while oily mixtures wereextracted with diethyl ether and subjected to flash chromatography on silica gel. Hexane-ethyl acetatewas used as the eluent in an appropriate ratio (70:30 (v/v), 80:20 (v/v) or 90:10 (v/v)). The fractionscontaining the desired compounds were combined and crystallized from absolute ethanol to obtainanalytically pure crystals.
The synthetic route of 22047-25-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Kucerova-Chlupacova, Marta; Vyskovska-Tyllova, Veronika; Richterova-Finkova, Lenka; Kunes, Jiri; Buchta, Vladimir; Vejsova, Marcela; Paterova, Pavla; Semelkova, Lucia; Jandourek, Ondrej; Opletalova, Veronika; Molecules; vol. 21; 11; (2016);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem