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Adding a certain compound to certain chemical reactions, such as: 32111-21-0, name is 2-Iodopyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 32111-21-0, Quality Control of 2-Iodopyrazine
Example 55; N-(3-(5-(4-chlorophenyl’>-4-oxo-6-f4-fpyrazin-2-vDphenyl’)-4.5-dihvdro- 1 H-pyrazolof 3.4- d]p yrirnidin- 1 -yDphenyPmethanesulfonamide; [00189] A solution of N-(3-{5-(4-chloro-phenyl)-4-oxo-6-[4-(4,4,5,5-tetramethyl-[ 1 ,3,2]dioxa-borolan-2-yl)phenyl]-4,5-dihydro-pyrazolo[3,4-d]pyriinidin-l -yl} -phenyl)- methane sulfonamide (prepared as described in example 35, 0.50 g, 0.81 mmol) in N,N- dimethylformamide (20 mL) is degassed with argon for 0.5 h. Then 2-iodopyrazine (0.25 g, 1.21 mmol), cesium carbonate (0.527 g, 1.61 mmol), Pd(dppf)2Cl2 (0.06 g, 0.082 mmol) are added and the resulting solution is degassed with argon for 0.5 h. The reaction mixture is then heated at 100 0C for 3 h. The reaction mixture is cooled to it and diluted with water and extracted with ethyl acetate (3 *). The combined organic layer is washed with brine, dried over Na2SO-I, concentrated, and purified by column chromatography to afford N-{3-[5-(4- chloro-phenyl)-4-oxo-6-(4-pyrazin-2-yl-phenyl)-4,5-dihydro-pytauazolo[3 ,4-d]pyrimidin- 1 -yl]- phenyl} -methane sulfonamide. 1H NMR (DMSO-d6, 400 MHz) delta 10.15 (br, 1 H), 9.26 (d, IH), 8.71 (d, IH), 8.62 (d, IH), 8.52 (s, IH), 8.06 (m, 3H), 7.82 (m, IH), 7.60 (m, 2H), 7.52 (m, IH), 7.40 (m, 4H), 7.18 (m, IH), 3.02 (s, 3H); LC-MS calculated for C28H20ClN7O3S (M+H+) 570.1, found 570.0.
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Reference:
Patent; IRM LLC; WO2007/120454; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem