According to the analysis of related databases, 1111638-10-8, the application of this compound in the production field has become more and more popular.
Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1111638-10-8, name is 3-Chloro-5H-pyrrolo[2,3-b]pyrazine, This compound has unique chemical properties. The synthetic route is as follows., category: Pyrazines
Preparation of 3-chloro-5-methyl-5H-pyrrolo[2,3-b]pyrazine (B-10-6).B-10-5 , B-10-6 A solution was made of 310 mg (1.95 mmol) of compound B-10-5 in 3 ml of anhydrous DMF. This mixture was added to a solution of 125 mg (3.05 mmol) of 60% NaH dispersion in mineral oil in 3 ml of anhydrous DMF. Another 6 ml of DMF was used to rinse the container. Let stir reaction mixture stir for 15 min at room temperature. Added another 150 mul (2.40 mmol) of MeI. Let stir for 2 hr. LCMS shows one peak M+H = 168 with Cl isotope pattern. The reaction mixture was poured into saturated NH4CI solution (100 ml) slowly, then extracted with EtOAc (3 x 50 ml). The organics were combined, dried over MgSO4 and filtered. Silicia gel chromoatography using EtOAc/Hexane gave 257 mg (76% yield) of compound B-10-6 as a yellow solid.
According to the analysis of related databases, 1111638-10-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PFIZER INC.; WO2009/16460; (2009); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem