In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1209646-17-2, name is 5-(4-(tert-Butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylic acid belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 5-(4-(tert-Butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylic acid
Method 19: Synthesis of 5-(5-{(R)-l-Cvclopropyl-l-r5-(3,4,5,6-tetrahvdro-2H- ri,2nbipyrazinyl-5′-yl)-ri,2,41oxadiazol-3-yll-ethyl}-pyridin-2-yl)-pyrimidin-2- ylamine (Example 134) Step 1: Synthesis of 1-25A suspension of 1- 18.3 (209 mg, 0.657 mmol) and CDI (102 mgs, 06328 mmol) in 1,4- dioxane (3 mL) in a sealed tube is stirred at 55 C for one hour. A solution of 1-8.10 (225 mg, 0.598 mmol) in dioxane (3ml) is added and the reaction mixture is stirred at 120 C for 18 hours. After cooling to room temperature, the reaction mixture is poured into brine and extracted with EtOAc (4x20ml). The combined organic fractions are dried with sodium sulfate, filtered, and is concentrated in vacuo. The resdiue is purified by flash chromatography (Si02, Biotage SNAP lOOg, 0-5 MeOH/DCM) to yield 1-25 (298 mg), m/z 649 [M+H]
The synthetic route of 1209646-17-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BARTOLOZZI, Alessandra; BOSANAC, Todd; CHEN, Zhidong; DE LOMBAERT, Stephane; HUBER, John, D.; LIU, Weimin; LO, Ho Yin; LOKE, Pui Leng; RIETHER, Doris; TYE, Heather; WU, Lifen; ZINDELL, Renee, M.; WO2012/40137; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem