Synthetic Route of 17890-77-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 17890-77-6 as follows.
To a solution of 3-amino-6-bromopyrazine-2-carboxamide (200 mg, 0.92 mmol) in triethoxymethane (10 mL) was added Ac20 (2 mL). The mixture was stirred at 130C for 1 h and 90C for 3 h. After being cooled to RT and extracted with EtOAc, the combined organic phaseswere basified to pH = 8 with a.q. NaHCO3, washed with brine, dried over Na2504, filtered andevaporated. The crude product was purified by prep-TLC (DCM : MeOH = 50: 1) to give theproduct of 6-bromopteridin-4(3H)-one (100 mg, yield: 48%). ?H-NMR (DMSO-d6, 400 MHz)8.59 (s, 1H), 7.89 (s, 1H). MS (M+H): 227 / 229.
According to the analysis of related databases, 17890-77-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; DAI, Xing; LIU, Hong; PALANI, Anandan; HE, Shuwen; NARGUND, Ravi; XIAO, Dong; ZORN, Nicolas; DANG, Qun; MCCOMAS, Casey C.; PENG, Xuanjia; LI, Peng; SOLL, Richard; WO2014/205593; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem