Electric Literature of 723286-80-4, A common heterocyclic compound, 723286-80-4, name is tert-Butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate, molecular formula is C10H15BrN4O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation 154: 3-bromo-5,6,7,8-tetrahydro-[1 ,2,4]triazolo[4,3-a]pyrazine To a solution of ie/i-butyl 3-bromo-5,6-dihydro-[1 ,2,4]triazolo[4,3-a]pyrazine- 7(8H)-carboxylate (52 mg, 0.172 mmol) in DCM (6 mL) at 0C was added TFA (0.26 mL). The reaction was stirred at room temperature for 16 hours before concentrating in vacuo. The residue was purified by elution through an SCX-2 column using 2M NHs/MeOH to give the title compound as yellow solid (29 mg, 83%). 1 H NMR (500 MHz, MeOD): delta 4.10 (s, 1 H), 3.93 (t, J = 5.63 Hz, 2H), 3.25 (t, J = 5.63 Hz, 2H). LCMS (ESI) Rt = 0.40 minutes MS m/z 203 [M79Br+H]+
The synthetic route of 723286-80-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; HOELDER, Swen; BLAGG, Julian; CHEUNG, Jack; ATRASH, Butrus; SHELDRAKE, Peter; WO2014/37751; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem