Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 486460-21-3, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, A new synthetic method of this compound is introduced below., Quality Control of 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
Example 5: Preparation of 7-((S)-3-hydroxy-4-(2,4,5-trifluorophenyl)butyryl)-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine (formula 7) [Show Image] 35 g of compound of formula 6a and 28.3 g of compound of formula 8 were dissolved in 364 mL dichloromethane, forming clear solution, which was pre-cooled to 16 C before adding of 23.5 mL N,N’-diisopropylcarbodiimide. During gradual addition (15 min) of carbodiimide, the temperature was maintained between 20 C to 25 C applying external cooling. After the addition, the reaction mixture was stirred at 23 C for 3 h and then aged 3 h at 0 C, forming white suspension of precipitated N,N’-diisopropylurea. Suspension was filtered and the precipitate was washed with 2 x 50 mL dichloromethane. Clear, yellowish-brown filtrate was washed with 360 mL of diluted hydrochloric acid (obtained from 350 mL of water and 7.0 mL of 6 N HCl), 380 mL 0.5 % aqueous sodium bicarbonate, and 350 mL water. Organic phase was evaporated at 50 C and 2 mbar, obtaining 58.4 g of clear, pale-brownish amber-like product of compound of formula 7, which solidified on standing. 1H NMR (DMSO-d6): delta 2.45-2.48(m, 1H), 2.65-2.78 (m,3H), 3.53-3.55(m, 2H), 3.96-4.21 (m,3H), 4.85-5.05(m,2H), 7.35-7.40 (m, 2H).
The synthetic route of 486460-21-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LEK Pharmaceuticals d.d.; EP2397141; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem