109-08-0, name is 2-Methylpyrazine, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 109-08-0
(1) Dissolve 9.41 g (0.1 mol) of 2-methylpyrazine in 30.0percent of 182.30 g of hydrochloric acid (containing 1.5 mol of hydrogen chloride).Under stirring, the temperature was controlled at 0-15¡ãC, and 25.32 g of a 25.0percent hydrogen peroxide solution was added dropwise.The reaction temperature was controlled at 0-15¡ãC to make the reaction system chlorinated. The reaction was sampled at regular intervals and detected by high performance liquid chromatography.When it was detected that the mass of 2-methyl-3-chloropyrazine in the reaction system accounted for 73.5percent of the total organic matter mass in the reaction system,The reaction was terminated by adding 17.21 g (0.12 mol) of cuprous bromide to obtain a 2-methyl-3-chloropyrazine-containing solution; (2) Add 63.78 g of methylene chloride to the feed solution, stir and extract for 2 hours, and let stand for 1 hour.Take the organic phase and allow it to cool down to -15¡ãC to -5¡ãC to allow solids to be analyzed from the organic phase.8.36 g of the resulting fixative is 2-methyl-3-chloropyrazine,After calculation, the yield was 65.5percent, and the main containment was 97.8percent.
The synthetic route of 109-08-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shandong Tianxin Chemical Co., Ltd.; Ju Youguo; Zhao Benteng; Wang Zewu; Yang Hanhua; Zhang Zhaoyuan; Liu Jian; Gong Fangxin; (6 pag.)CN107954913; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem