Related Products of 912773-21-8,Some common heterocyclic compound, 912773-21-8, name is 2-Bromo-5-chloropyrazine, molecular formula is C4H2BrClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of tert-butyl (3aR, 5s,6a5)-5-aminohexahydrocyclopenta[c]pyrrole-2( 1 H)-carboxylate (274 mg, 1.21 mmol) in NIVIP (4.5 mL) was added 2-bromo-5-chloropyrazine (585 mg, 3.02 mmol) and J7N- diisopropylethylamine (0.63 mL, 3.63 mmol). The mixture was stirred at 180 C under microwave irradiation for 1 h. Solids were removed by syringe filtration, and crude residue was purified by RP-HPLC (20-70% MeCN in 0.05% NH4OH aqueous solution over 20 mm). Fractions containing product were combined and concentrated to give the title compound as a brown oil (148 mg, 32%). ES-MS [M+H]b = 383.2.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Bromo-5-chloropyrazine, its application will become more common.
Reference:
Patent; VANDERBILT UNIVERSITY; LINDSLEY, Craig, W.; CONN, P., Jeffrey; ENGERS, Darren, W.; ENGERS, Julie, L.; TEMPLE, Kayla, J.; BENDER, Aaron, M.; BAKER, Logan A.; (221 pag.)WO2019/79783; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem