Related Products of 16298-03-6, These common heterocyclic compound, 16298-03-6, name is Methyl 2-aminopyrazine-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step B: Methyl 3-[(4-methyl-1-naphthoyl)amino]pyrazine-2-carboxylate; At 90 ¡ãC a solution of 4-methyl-1-naphthalenecarbonyl chloride (12 mmol) in CH2CICH2CI (20 mL) was slowly added into a solution of methyl 3-aminopyrazine-2- carboxylate (1.53 g, 10.0 mmol) and DMAP (100 mg) in CH2CICH2CI (100 mL) and pyridine (10 mL) during a period of six hours. The resulting reaction mixture was stirred at the same temperature overnight, and was then condensed, and extracted by EtOAc, washed by brine, dried over MgS04. Removal of solvents provided a crude product, which was purified by flash silica gel column using heptane/EtOAc (10: 0 to 0: 10) to give the title product as a solid (1.5 g, 47 percent) : 1H NMR (400 MHz, CDC13) No. 1H NMR (400 MHz, CD30D) 2.77 (s, 3H), 3.94 (s, 3H), 7.46 (d, J=8.0 Hz, 1H), 7.60 (m, 2H), 7.79 (d, J=8.0 Hz, 1H), 8.14 (d, J=8.0 Hz, 1H), 8.42 (m, lH), 8.50 (m, 1H), 8.64 (m,lH).
The synthetic route of 16298-03-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AstraZeneca AB; WO2005/115986; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem