Related Products of 13134-31-1, These common heterocyclic compound, 13134-31-1, name is 2,3-Diaminopyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 2,3-diaminopyrazine (55mg, 0.5mmol) and methyl 1-({5-chloro-2-[(2- methylpropyl)oxy]phenyl}methyl)-5-methyl-1/-/-pyrazole-3-carboximidoate hydrochloride (186mg, O.deltammol) in ethanol (4ml) was stirred and refluxed for 4 hours. The solid which separated was filtered, dissolved in hot methanol and 1 M hydrogen chloride in ether (0.5ml) added. The solution was evaporated to dryness and the residue triturated with ether to give the title compound as an off-white solid (17mg). LC/MS Rt 3.10, [MH]+ 397.2, 399.2
The synthetic route of 13134-31-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; WO2006/114313; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem