Related Products of 723286-80-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 723286-80-4 as follows.
A mixture of tert-butyl 3-bromo-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylate (1.65 mmol, 500 mg), 1-chloro-3-ethynyl-benzene ( 3.3 mmol, 450.5 mg, 0.406 mL), Pd tetrakis (0.083 mmol, 95.3 mg) and sodium acetate (3.3 mmol, 448.9 mg) in DMF anhydrous (10 mL) was stirred at 120C in a MW Biotage Robot 8 oven for 10 minutes, cooled to r.t., poured into water and extracted with EtOAc. The combined organic layers were washed with brine and dried over Na2SO4. The solvent was removed in vacuo and the crude residue was purified via automated flash chromatography (Biotage Isolera, SNAP25 cartridge) eluted with Petroleum ether/EtOAc gradient from 30% to 100% of EtOAc. (0197) The title product (280 mg, 47 % yield) was isolated as a pale yellow solid.
According to the analysis of related databases, 723286-80-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.P.A; GRAZIANI, Davide; RIVA, Carlo; MENEGON, Sergio; TAZZARI, Valerio; (98 pag.)WO2019/145214; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem