Adding a certain compound to certain chemical reactions, such as: 132426-19-8, name is 2-Bromo-1-(pyrazin-2-yl)ethanone, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 132426-19-8, Recommanded Product: 132426-19-8
Step 1. 3-Amino-6-chloro-1-(ethoxycarbonyl)-2-(pyrazine-2-carbonyl)indole The title compound was prepared according to the procedure described in step 2 of Example 1 from 4-chloro-2-(ethoxycarbonylamino)benzonitrile (Example 1, step 1) and 2-(bromoacetyl)pyrazine (prepared according to the method of F. H. Case et al., J. Am.Chem.Soc., 1956, 78, 5842). 1H-NMR (CDCl3) delta: 9.26 (1H, d, J=1.5 Hz), 8.67 (1H, d, J=2.6 Hz), 8.56 (1H, dd, J=1.5, 2.6 Hz), 8.21 (1H, d, J=1.8 Hz), 7.55 (1H, d, J=8.4 Hz), 7.27 (1H, dd, J=1.5, 8.4 Hz), 6.18 (2H, br s), 3.87 (2H, q, J=7.0 Hz), 0.93 (3H, t, J=7.0 Hz)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-1-(pyrazin-2-yl)ethanone, and friends who are interested can also refer to it.
Reference:
Patent; Pfizer Inc.; US6300363; (2001); B1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem