Adding a certain compound to certain chemical reactions, such as: 33332-25-1, name is Methyl 5-chloropyrazine-2-carboxylate, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33332-25-1, SDS of cas: 33332-25-1
4-((7-azaspiro[3.4]nonan-2-oxy)methyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole (100 mg, 0.24 mmol) is dissolved in DMF (5 mL), followed by adding methyl 5-chloropyrazine -2-carboxylate (45 mg, 0.26 mmol) and potassium carbonate (81 mg, 0.59 mmol), and the mixture is heated to 80 C and continues to react for 2 hr. Then the reaction mixture is cooled down to room temperature, poured into water (20 mL), and extracted with ethyl acetate (15 mL * 2) and the organic layer is washed with saturated salt solution (20 mL * 2), then dried with anhydrous Na2SO4, filtered, rotated to dryness and purified by column chromatography (PE : EA = 1.5 : 1), so as to obtain a brown oily matter of 100 mg, that is methyl 5-(2-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)-6-azaspiro[3.4]octan-6-yl)pyr azine-2-carboxylate with a yield of 81%. Spectrum is: 1H NMR (400 MHz, CDCl3) delta: 8.81(m, 1H), 7.86(m, 1H), 7.46-7.44(m, 2H), 7.39-7.34(m, 1H), 4.21(s, 2H), 3.97(m, 4H), 3.58-3.44(m, 4H), 2.16(m, 3H), 1.98(m, 2H), 1.83(m, 2H), 1.29(m, 2H), 1.15(m, 2H).
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Reference:
Patent; Guangzhou Henovcom Bioscience Co. Ltd.; ZHANG, Jiancun; ZOU, Qingan; CHEN, Yanwei; (64 pag.)EP3401315; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem