136927-64-5, name is 1-Chloropyrrolo[1,2-a]pyrazine, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C7H5ClN2
Compound C28 (150 mg, 0.500 mmol), 1-chloropyrrolo[1,2-a]pyrazine (76 mg,0.50 mmol), cesium carbonate (488 mg, 1.50 mmol), palladium(ll) acetate (12 mg, 50pmol), and di-teit-butyl [3,4, 5,6-tetramethyl-2?,4? ,6?-tri(propan-2-yl) biphenyl-2- yl]phosphane (47 mg, 98 pmol) were combined in 1,4-dioxane (3 mL), and the reaction was degassed with nitrogen for 5 minutes. After the reaction mixture had been heated to 120 00 in a microwave for 3 hours, it was cooled to room temperature and filteredthrough diatomaceous earth; the filter cake was rinsed with ethyl acetate. The combined filtrates were concentrated in vacuo and the crude residue was purified via silica gel column chromatography (Gradient: 0% to 100% ethyl acetate in heptane) to provide the desired product as a yellow oil. Yield: 159 mg, 0.38 mmol, 77%. LCMS m/z 417.2 [M+H]. 1H NMR (400 MHz, CDCI3) characteristic peaks oe 7.62 (dd, J=1.0, 4.7Hz, 1H), 7.46 (dd, J=1.4, 2.5 Hz, 1H), 7.40 (brs, 1H), 7.38 (brs, 1H), 7.21-7.14 (m, 2H),7.08 (d, J=4.9 Hz, 1H), 6.99-6.97 (m, 1H), 6.85 (dd, J=4.1, 2.7 Hz, 1H), 6.15 (dd, J=11.0, 2.1 Hz, 1H), 4.20-4.17 (m, 1H), 3.80 (dt, J=11.5, 2.5 Hz), 2.12 (5, 3H), 2.01 (5, 3H).
The synthetic route of 136927-64-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER INC.; GRAY, David Lawrence Firman; DAVOREN, Jennifer Elizabeth; DOUNAY, Amy Beth; EFREMOV, Ivan Viktorovich; MENTE, Scot Richard; SUBRAMANYAM, Chakrapani; WO2015/166370; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem