The synthetic route of 16298-03-6 has been constantly updated, and we look forward to future research findings.
16298-03-6, name is Methyl 2-aminopyrazine-3-carboxylate, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: Methyl 2-aminopyrazine-3-carboxylate
Preparation of 3-aminopyrazine-2-carbaldehyde EPO Mpsithyl-3-aminopyrazine-2-carboxylate (11g) was dissolved in THF and cooled to – 780C. Diisobutylaluminum hydride (1 M in hexanes, 25OmL) was added, and the reaction stirred at -78¡ãC for 4 hours. The reaction was then warmed to 00C for one hour before being quenched slowly by addition of 1 M hydrochloric acid. Ethyl acetate was added and the layers separated. The organic layer was dried over magnesium sulfate, filtered and concentrated. The residue was triturated in hexanes to afford title compound (3.Og, 34percent).1H NMR (400 MHz, DMSO-D6) delta ppm 7.73 (br, 2H), 8.07 (d, J=2.25 Hz, 1 H), 8.36 (d, J=2.11 Hz, 1 H), 9.95 (s, 1 H).
The synthetic route of 16298-03-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2006/63167; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem