These common heterocyclic compound, 193966-70-0, name is Methyl 5-(bromomethyl)pyrazine-2-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C7H7BrN2O2
[0116j To a solution of methyl 5-(bromomethyl)pyrazine-2-carboxylate (0.15 g, 0.65 mmol) in chloroform (10 mL) was added hexamethylene tetramine (0.093 g, 0.66 mmol) and the reaction mixture was stirred at room temperature for 18 h. The solid formed was filtered and dried. The solid was suspended in methanol (10 mL), concentrated hydrochloric acid (0.3 ml) was added and the reaction mixture was heated at 75 C for 3 h. The reaction mixture was concentrated, the residue was triturated with diethyl ether and dried to afford the title compound methyl 5-(aminomethyl)pyrazine-2-carboxylate hydrochloride (0.15 g, crude) as a brownish solid. Calculated M+H: 168.07; Found M+H: 168.1.
The synthetic route of Methyl 5-(bromomethyl)pyrazine-2-carboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MNEMOSYNE PHARMACEUTICALS, INC.; ANDERSON, David R.; VOLKMANN, Robert A.; WO2015/48503; (2015); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem