These common heterocyclic compound, 63744-22-9, name is 6,8-Dibromoimidazo[1,2-a]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 6,8-Dibromoimidazo[1,2-a]pyrazine
To a solution of 6,8-dibromoimidazo[l,2-a]pyrazine (0.50 g, 1.8 mmol) [Combi- Blocks, OR-7964] in DMF (12 mL) was added N-iodosuccinimide (0.45 g, 2.0 mmol). The reaction mixture was then heated at 60 C for 15.5 h. The reaction mixture was concentrated in vacuo. The resulting solid was taken up into dichloromethane (DCM). The organic layer was washed sequentially with water and sat. Na2S203 (aq). The organic layer was then dried over Na2S04, filtered, and concentrated to afford the title compound as a light yellow solid (0.64 g, 88%). LCMS for CeltBrzINs (M+H)+: calculated m/z = 401.8, 403.8, 405.8; found 401.8, 403.7, 405.6.
The synthetic route of 6,8-Dibromoimidazo[1,2-a]pyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; INCYTE CORPORATION; DOUTY, Brent; BUESKING, Andrew W.; BURNS, David M.; COMBS, Andrew P.; FALAHATPISHEH, Nikoo; JALLURI, Ravi Kumar; LEVY, Daniel; POLAM, Padmaja; SHAO, Lixin; SHEPARD, Stacey; SHVARTSBART, Artem; SPARKS, Richard B.; YUE, Eddy W.; (355 pag.)WO2019/79469; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem