Application of 4858-85-9, These common heterocyclic compound, 4858-85-9, name is 2,3-Dichloropyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 2,3-dichloropyrazine (5) (2000mg, 13.42mmol) LHMDS (6.0ml, 30.87mmol) (1M in THF) under nitrogen condition was added dropwise a soution of ethyl acetate (1.44ml, 14.76mmol) in toluene (20ml) .The reaction mixture was stirred at room temperature for 24 h. Then, the reaction mixture was diluted with Et2O and was quenched with saturated aq. NH4Cl. The two layers were separated and the aq. one was further extracted with Et2O. The combined organic layers were washed with brine, dried over MgSO4 and concentrated in vacuo. The crude was then purified by flash column chromatography (EtOAc/Heptane, 15:85). The desired fractions were concentrated to dryness in vacuo to afford 3 (1850mg, 8.76mmol, 65%) as a pale yellow oil.
Statistics shows that 2,3-Dichloropyrazine is playing an increasingly important role. we look forward to future research findings about 4858-85-9.
Reference:
Article; Luise, Nicola; Wyatt, Paul G.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 2; (2019); p. 248 – 251;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem