Some common heterocyclic compound, 56423-63-3, name is 2-Bromopyrazine, molecular formula is C4H3BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 56423-63-3
5- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) -3,6-dihydropyridine-1 (2H) -carboxylic acid Tert-butyl ester (200mg, 0.65mmol)And 3-bromopyridine (51.1mg, 0.323mmol) into a bottle,Add 1,2-dimethoxyethane (4 mL)And 2M aq. Na2CO3 (1.5 mL).After removing oxygen from the reaction system, Pd (dppf) Cl2-CH2Cl2 (26.4 mg, 0.032 mmol) was added.The reaction was heated at 95 C overnight, diluted with water and extracted with ethyl acetate.Dry and concentrated,Purification by column gave the target compound YB119.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 56423-63-3, its application will become more common.
Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhao Yujun; Li Jia; Wang Zengtao; Zhang Shiyan; Zang Yi; Wang Peipei; Sun Dandan; Zhang Hanyan; (155 pag.)CN110818683; (2020); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem