Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 23688-89-3, name is 6-Chloropyrazine-2-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 23688-89-3
6-Chloropyrazine-2-carboxylic acid [CAS RN: 23688-89-3] (565 mg, 3.56 mmol,1.0 eq) was dissolved in 8 mL THF, and CDI (578 mg, 3.56 mmol, 1.0 eq) was added. Then, the reaction mixture was heated to 70C for 2 h. In a separate flask, 1 -(2,2,2-trifluoroethyl)piperidin-4-amine dihydrochloride [Intermediate13] (936 mg, 3.67 mmol, 1.03 eq) was dissolved in THF and triethylamine (1.02 mL, 7.34 mmol, 2.06 eq) was added. Then, this solution was added to thesolution of the preformed imidazolide and the reaction mixture was heated again to 70C for 2 h. The volatile components were removed in vacuo and the crude material, was purified via preparative MPLC (Biotage Isolera; 25 g SNAP cartridge: hexane -> hexane/ethyl. acetate 2/1) to give 558 mg (44% yield of theory) of the title compound.UPLC-MS (Method 1): R = 0.95 mm; MS (EI0): m/z = 323 [M+H].1H-NMR (400 MHz, DMSO-d6): oe [ppm] = 1.63-1.79 (m, 4H), 2.43 (m, 2H), 2.92 (m, 2H), 3.16 (q, 2H), 3.80 (m, 1H), 8.70 (d, 1H), 8.99 (s, 1H), 9.10 (s, 1H).
According to the analysis of related databases, 23688-89-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; SIEMEISTER, Gerhard; HEINRICH, Tobias; PRECHTL, Stefan; STOeCKIGT, Detlef; ROTTMANN, Antje; WO2015/113927; (2015); A1;,
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