Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 56423-63-3, name is 2-Bromopyrazine, A new synthetic method of this compound is introduced below., Quality Control of 2-Bromopyrazine
To a reaction flask were added compound 21 (100 mg, 0.186 mmol), 2-bromopyrazine (50 mg, 0.279 mmol), Pd(dppf)Cl2 (5 mg, 0.006 mmol) and sodium carbonate (60 mg, 0.558 mmol), 5 mL glycol dimethyl ether and 0.9 mL water were added, bubbled with nitrogen gas for 10 minutes, and the reaction was heated to 100 C in microwave and reacted for half an hour. After TLC detected the reaction was complete, the reaction was concentrated, purified by silica gel column chromatography to afford 72 mg of a product, yield: 79.1%. LC-MS(APCI): m/z = 489.7 (M+1)+. 1H NMR (400 MHz, CDCl3) delta 8.77 (d, J = 2.2 Hz, 1H), 8.71 (s, 1H), 8.63 (s, 1H), 8.52 (d, J = 2.4 Hz, 1H), 8.09 (d, J = 2.3 Hz, 1H), 8.00 (s, 1H), 7.69 (d, J = 9.0 Hz, 2H), 7.23 (d, J = 8.8 Hz, 2H), 3.45 – 3.36 (m, 1H), 3.27 (dt, J = 20.1, 8.5 Hz, 3H), 2.75 – 2.66 (m, 1H), 2.23 (s, 6H), 2.06 (dd, J = 11.1, 5.1 Hz, 1H), 1.85 – 1.74 (m, 1H).
The synthetic route of 56423-63-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shenzhen Targetrx, Inc.; WANG, Yihan; ZHAO, Jiuyang; AL, Yixin; (55 pag.)EP3553056; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem