Electric Literature of 19745-07-4,Some common heterocyclic compound, 19745-07-4, name is 2,5-Dichloropyrazine, molecular formula is C4H2Cl2N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a sealed vessel, a mixture of tert-butyl (4-methylpiperidin-4-yl)carbamate (1.44 g, 6.71 mmol), 2,5-dichloropyrazine (1.00 g, 6.71 mmol) and K2C03(S) (4.64 g, 33.6 mmol) in dioxane (67.1 mL) was stirred for 60 h at 60 ¡ãC. After cooling to ambient temperature, the resulting suspension was diluted with EtOAc, filtered through Celite ? then concentrated in vacuo. The crude residue was purified by silica chromatography (0-100percent) EtOAc in hexanes) to afford the title compound (657 mg, 30percent yield). MS (apci) m/z = 327.1 (M+H).
The synthetic route of 19745-07-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ANDREWS, Steven W.; ARONOW, Sean; BLAKE, James F.; BRANDHUBER, Barbara J.; COLLIER, James; COOK, Adam; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; MCFADDIN, Elizabeth A.; MCKENNEY, Megan L.; MCNULTY, Oren T.; METCALF, Andrew T.; MORENO, David A.; RAMANN, Ginelle A.; TANG, Tony P.; REN, Li; WALLS, Shane M.; (946 pag.)WO2018/71454; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem